Increasing NAD+ Levels for Immunity Against Viral Replication

The recent updates regarding the pandemic don’t seem to slow down, therefore, inflicting an increased level of stress and anxiety to most people. Health and science experts continue to search for faster, and effective solutions to save the lives of the infected. In this new research, experts talk about the benefits of NAD+ in boosting immunity and fighting virus infection.

What is NAD+?

Involved in hundreds of metabolic processes, NAD+ (nicotinamide adenine dinucleotide) is a coenzyme in every cell of the body that serves as a helper molecule that is key to cellular energy production. However, NAD+ levels decrease by half of what it used to have during the natural process called aging.

It has five precursors, namely:

  • Nicotinamide Mononucleotide (NMN) 
  • Nicotinamide Riboside (NR)
  • Nicotinic Acid (NA)
  • Nicotinamide (Nam)
  • Tryptophan (Trp) 

What is the importance of raising NAD+ levels?

Scientists have shared researches on how boosting NAD+ levels may help:

  • Promote longevity, turning on longevity-promoting proteins called sirtuins
  • Defend against oxidative stress 
  • Repair DNA damage, creating the building blocks for DNA and RNA, and to turn on ‘longevity-promoting’ proteins called sirtuins.

The Recent Research on Raising NAD+ Levels for Immunity Against the Pandemic

There is preclinical research that demonstrated raising your NAD+ levels can help boost the activity of protective enzymes called PARPs and reduce coronavirus replication.

 

COVID-19 has been shown to damage the lung cells in part by depleting levels of the metabolite NAD+, which is essential in helping to repair inflammatory DNA damage and support cell survival. This makes NAD+ a key target for fighting against the disease. In recent reports from the University of Iowa, Oregon Health & Science University, and the University of Kansas researchers, levels of NAD+ in cells were decreased by 80% after infection with a form of coronavirus. The loss of NAD+ appeared to worsen cell survival and impair immune cells like macrophages from combatting the virus.

  • the activity of antiviral PARP enzymes, the key to a strong innate immune response, were upregulated by boosting NAD+
  • Coronaviruses respond with their own countermeasure with an enzyme called poly-ADP ribose glycohydrolase (PARG), that functions to disable PARPs
  • hypothesized that NAD+ depletion may worsen the “cytokine storm” that results in the fatal acute respiratory distress syndrome (ARDS) seen in some COVID patients 
  • gene expression data identified NAM, NAMPT activators and NR to have similar potential to be strongly protective in vivo

Ways to increase Your NAD+ Levels

Here are simple ways to increase your NAD+ levels and start building a healthy immune system to fight the pandemic!

    • REGULAR EXERCISE. The health benefit of regular exercise is because of the fact that the human body gathers energy from NAD+. Exercise then makes our body muscles work effectively to produce more mitochondria. The increased production of mitochondria gives a natural boost in the body’s NAD+ levels. 
    • HEALTHY FASTING. How does fasting contribute to the increased biosynthesis of NAD within the cells? Fasting increases the levels of NAD+ and sirtuins; the proteins which have been found to slow the aging process as well.
    • NAD-BOOSTING MENU. Foods such as milk, fish, mushroom, yeast, green veggies, chicken, and whole grains are found to be good sources of NR AND Vitamin B3, which help boost your NAD+ levels.
    • NAD BOOSTERS (SUPPLEMENTS). NAD-boosting supplements became available in the markets soon after Dr. Brenner’s research on healthy cellular aging has been released. S-CELL has the NAD supplement aimed at boosting cellular NAD+ energy levels to healthy aging including ingredients that help strengthen your immune system.